Jun
21 2010
- Flucloxacillin – hepatic disorder, hepatitis can occur even after Tx stopped
- Co-amoxiclav – cholestatic jaundice, >common over 65yrs, tx should not be > 14 days
- Tobramycin (nebs) – use other inhalers first, then tobramycin nebs, monitor bronchospasm, can cause severe haemoptysis
- Telithromycin - 1. hepatic disorder – dark urine, jaundice, N+V, 2. driving – visual disturbance, loss of consciousness, so admin at bedtime
- Clindamycin - diarrhoa – fatal, discontinue if diarrhoa develops
- Chloramphenicol – blood disorders
- Daptomycin – muscle effects
- Linezolid – 1. blood disorders 2. optic neuropathy 3. it is a reversible MAO i, avoid large amount of tyramine food, avoid concomitant MAOi, TCA, SSRI
- Co-trimoxazole – use for acute exacerbation of chronic bronchitis and UTI with good reasons, can cause blood disorders, bone marrow supp, agranulocytosis
- Trimethoprim – blood disorders
- Isoniazid – hepatic disorder, peripheral neuropathy (give pyridoxine)
- Pyrazinamide – hepatic disorder
- Rifampicin – hepatic disorder, discolouration of soft contact lense, extra contraceptive measures
- Ethambutol – visual disturbances
- Ciprofloxacin – not for children due to arthropathy, tendonitis – concomitant use of corticosteroid increases risk
- Amphotericin – anaphylaxis reaction with IV, test dose
- Itraconazole – hepatotoxicity and heart failure – cautious
- Ketoconazole – hepatotoxicity
- Nucleoside reverse transcriptase inhibitor – Lactic acidosis in hepato impairment, pancreatitis – i.e. Didanosine
- Abacavir – hypersensitivity
- Protease inhibitor – hyperglycaemia, cautious with diabetes
- Non-nucleoside RTI – Rash and Psychiatric problems
Extra Bits
Strains – staphylococcus, and pseudomonas aer
Staphylococcus – gram +ve, normally affects skin and nose
Staph Aureus – boils, impetigo, pimples, cellulitis
More serious infections – pneumonia, meningitis, endocarditis
Tx – Penicillin, but due to increase resistance, Flucloxacillin is 1st line
Pseudomonas aeruginosa – gram -ve, UTI, GI, Lungs
Resistant - penicillin and B-lactam Abx
Tx - quinolones, antipseud penicillin, aminoglycosides, cephalosporin
Broad Spectrum Abx
- Penicillin – ampicillin, amoxicillin
- Cephalosporin
- Chloramphenicol
- Tetracyclines
- Macrolides
- Aminoglycosides
- Carbemenems
Misc
- Aztreonam (beta-lactam) - Only active against Gram -ve , less likely to cause hypersensitivity in penicillin sensitive patients
- Polymyxins – Active against Gram -ve , can cause nephro and neurotox
- Linezolid – Only active against Gram +ve – MRSA, alternative to vancomycin
- Clindamycin – Only active against Gram +ve, active against anaerobes, joints and bones infection
- Metronidazole – Active against anaerobes
- Aminoglycosides – Inactive against anaerobes
- Fusidic Acid – Narrow Spectrum – joints and bones infection
June 21st, 2010 at 8:42 pm
WOW u are learning ALOT! Your scaring me! I havnt learnt all this…its like too much for me to learn now….sighh…goodluck!
June 21st, 2010 at 10:03 pm
Hey Harps,
I dont think I can even retain all!! Frankly i havnt done many chapters. but Im going through chaps 1-6.. no time!!!
June 22nd, 2010 at 8:13 pm
Hey Harps – please don’t worry yourself I havent learnt that either. Likelihood of it coming up on Friday is really really small.
June 24th, 2010 at 11:36 am
Hey,
Love your notes, they are excellent and have inspired me to write some of my own on my face book page to share with my friends…iv incorporated some of your notes in mine too – i hope you dont mind..
Good luck for the exam
Thanks alot for posting them up here !!
June 24th, 2010 at 11:48 am
Maya,
Thanks! Ya, exam tomorrow! *sweats* No problem, I just extracted the important bits from BNF. Share it with anyone.
June 24th, 2010 at 11:53 am
Stay cool calm and collected!!
Have something to eat, and grab a sugary drink for the duration–boost brain glucose levels..i normally have a chocolate bar before entering exam…
June 24th, 2010 at 2:07 pm
thanks!! going to cardiff in 2 hours time for the night, u having exam tomorrow as well?
June 24th, 2010 at 2:49 pm
Yes i am doing the exam tomorow too! But i am based in london. I guess we have different examination centres.
Have a safe journey and Make sure you sleep well
June 27th, 2010 at 9:36 pm
How was the exam friends ?? Was very tough for me. Hope all pass.
Shan
June 27th, 2010 at 10:29 pm
hey..
yea i wonder how everyone else did for the exam???
Shan – I thought it wasn’t easy, many tricky questions, i was worried about calcs most before the exam, and i thought the calcs was fine.. the open book as usual, lack time, i finished right on the dot, as for close book, quite difficult, at least more difficult than sample past papers. well good luck everyone for the results.
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